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- Diabetes, Obesity and Metabolism
- Association of Protein Z with Prediabetes and Type 2 Diabetes (Endocrinol Metab 2021;36:637-46, Yun-Ui Bae et al.)
- Ji Hong You, Yun-Ui Bae, Ho Chan Cho
- Endocrinol Metab. 2021;36(5):1149-1150. Published online September 16, 2021
- DOI: https://doi.org/10.3803/EnM.2021.502
- [Original]
- 2,667 View
- 76 Download
Original Article
- Diabetes, Obesity and Metabolism
- Association of Protein Z with Prediabetes and Type 2 Diabetes
- Yun-Ui Bae, Ji Hong You, Nan Hee Cho, Leah Eunjung Kim, Hye Min Shim, Jae-Hyung Park, Ho Chan Cho
- Endocrinol Metab. 2021;36(3):637-646. Published online June 2, 2021
- DOI: https://doi.org/10.3803/EnM.2021.962
- 5,171 View
- 147 Download
- 3 Web of Science
- 5 Crossref
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Abstract
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Supplementary Material
PubReader 
ePub - Background
Type 2 diabetes mellitus (T2DM) is a progressive metabolic disease. Early detection of prediabetes is important to reduce the risk of T2DM. Some cytokines are known to be associated with T2DM. Therefore, we aimed to identify cytokines as novel biomarkers of glucose dysmetabolism.
Methods
The first stage of the study included 43 subjects (13 subjects with newly diagnosed T2DM, 13 with prediabetes, and 16 with normoglycemia) for cytokine microarray analysis. Blood samples of the subjects were assessed for 310 cytokines to identify potential indicators of prediabetes. The second stage included 142 subjects (36 subjects with T2DM, 35 with prediabetes, and 71 with normoglycemia) to validate the potential cytokines associated with prediabetes.
Results
We identified 41 cytokines that differed by 1.5-fold or more in at least one out of the three comparisons (normoglycemia vs. prediabetes, normoglycemia vs. T2DM, and prediabetes vs. T2DM) among 310 cytokines. Finally, we selected protein Z (PROZ) and validated this finding to determine its association with prediabetes. Plasma PROZ levels were found to be decreased in patients with prediabetes (1,490.32±367.19 pg/mL) and T2DM (1,583.34±465.43 pg/mL) compared to those in subjects with normoglycemia (1,864.07±450.83 pg/mL) (P<0.001). There were significantly negative correlations between PROZ and fasting plasma glucose (P=0.001) and hemoglobin A1c (P=0.010).
Conclusion
PROZ levels were associated with prediabetes and T2DM. We suggest that PROZ may be a promising biomarker for the early detection of prediabetes. Further large-scale studies are needed to evaluate the relationship and mechanism between PROZ and prediabetes and T2DM. -
Citations
Citations to this article as recorded by
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Computational and Structural Biotechnology Journal.2023; 21: 1092. CrossRef - Role of F-box WD Repeat Domain Containing 7 in Type 1 Diabetes
Sarah W. Mohammed, Zainab M. Qassam, Ekhlass M. Taha, Nameer M. Salih
Ibn AL-Haitham Journal For Pure and Applied Sciences.2023; 36(3): 167. CrossRef - Identification of Protein Z as a Potential Novel Biomarker for the Diagnosis of Prediabetes
Seung-Hoi Koo
Endocrinology and Metabolism.2021; 36(3): 572. CrossRef - Association of Protein Z with Prediabetes and Type 2 Diabetes (Endocrinol Metab 2021;36:637-46, Yun-Ui Bae et al.)
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Endocrinology and Metabolism.2021; 36(5): 1149. CrossRef - Association of Protein Z with Prediabetes and Type 2 Diabetes (Endocrinol Metab 2021;36:637-46, Yun-Ui Bae et al.)
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Endocrinology and Metabolism.2021; 36(5): 1147. CrossRef
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